Environment, Occupation and Health

Exposures indoors, outdoors and at work contribute substantially to the global burden of morbidity and mortality caused by infectious and non-communicable diseases. In the Research Unit for Environment, Occupation and Health, we work with the impact of environmental factors, including occupational exposures, on health.

We develop methods to assess environmental and occupational exposures - from biomarkers to job exposure matrices and spatial models. We also develop methods for targeted prevention of diseases related to environmental and occupational exposures.

Examples of current research areas are occupational and environmental epidemiological studies within the broad areas of airway diseases and other inflammatory disease, allergy, cancer and birth outcomes. Assessment of acute humane health effects of controlled exposures in human exposure chambers is another example.

We are a highly collaborative and international research unit with a focus on the interplay between environment and health. The unit counts full professors, associate/assistant professors, highly specialized technicians, several post docs, PhD students, and pre-graduate students involved in numerous national and international research groups as well as research centers.

Methods

In the research unit, we make use of a broad variety of methods:

  • We conduct epidemiological studies on environment, occupation and health among human cohorts based on original research data and administrative registers.
  • We use big data to develop individual exposure measures using e.g. GIS, person-borne sensors, job exposure matrices and different modelling approaches.
  • We measure exposures in the environment (e.g. microbial exposures, particles).
  • We analyse environmental and human samples in our lab (e.g. endotoxin, allergens) and with collaborating labs, including microbiome analysis, next generation sequencing, genomics and proteomics.
  • We perform clinical investigations (e.g. lung function, allergy test, exhaled breath, nasal lavage).
  • We conduct human RCT experiments with airborne contaminants under strict climate control in our human exposure chamber.

Recent publications

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Olivieri, M., Heinrich, J., Schlünssen, V., Antó, J. M., Forsberg, B., Janson, C., Leynaert, B., Norback, D., Sigsgaard, T., Svanes, C., Tischer, C., Villani, S., Jarvis, D. & Verlato, G. (2016). The risk of respiratory symptoms on allergen exposure increases with increasing specific IgE levels. Allergy: European Journal of Allergy and Clinical Immunology, 71(6), 859-868. https://doi.org/10.1111/all.12841
Andersson, K., Christensen, O., Falk, J., Hempel-Jørgensen, A., Juto, J.-E., Kjærgaard, S. K., Mølhave, L. & Stridh, G. (2000). The relation between aldehydes in indoor air climate and irritation to mucous membranes in humans: Report on a climate chamber study (DSN-3). (IMA report no. 2000.1 ed.).
Andersson, K., Christensen, O., Falk, J., Hempel-Jørgensen, A., nullJ-E., J., Kjærgaard, S. K., Mølhave, L. & Stridh, G. (2000). The relation between alcohols in indoor air climate and irritation to mucous membranes in humans: A climate chamber study: Report on study DSN4, APU 2000. Paper presented at Department of Environmental and Occupational Medicine, University of Aarhus.
Schlünssen, V., Mandrioli, D., Pega, F., Momen, N. C., Ádám, B., Chen, W., Cohen, R. A., Godderis, L., Göen, T., Hadkhale, K., Kunpuek, W., Lou, J., Mandic-Rajcevic, S., Masci, F., Nemery, B., Popa, M., Rajatanavin, N., Sgargi, D., Siriruttanapruk, S. ... Scheepers, P. T. J. (2023). The prevalences and levels of occupational exposure to dusts and/or fibres (silica, asbestos and coal): A systematic review and meta-analysis from the WHO/ILO Joint Estimates of the Work-related Burden of Disease and Injury. Environment International, 178, Article 107980. https://doi.org/10.1016/j.envint.2023.107980
Hinson, A. V., Schlünssen, V., Agodokpessi, G., Sigsgaards, T. & Fayomi, B. (2014). The prevalence of byssinosis among cotton workers in the north of Benin. International Journal of Occupational and Environmental Medicine, 5(4), 194-200. http://www.ncbi.nlm.nih.gov/pubmed/25270009

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