Epidemiology

The Research Unit for Epidemiology develops and delivers teaching and research in human epidemiology. Our research includes epidemiological themes such as diet, lifestyle, reproduction, vaccines, environment, genetics and medication. And we find common ground in the application of epidemiological methods to address health challenges.

We work with a wide set of national and international collaborators at leading research centres, and our vision is to develop into one of the global centres of research excellence in epidemiology by developing a portfolio of research projects that apply state-of-the-art epidemiological methods to resolve societally and academically important research questions.

The research unit’s research covers different epidemiological aims, such as:

  • descriptive epidemiology of trends in the occurrence of conditions and diseases, their risk factors and complications based on Danish and international register data,
  • aetiological observational epidemiology examining the contribution of a wide variety of physiological, behavioural, societal and genetic mechanisms to the risk of health outcomes, including diseases and their complications, using both Danish and international cohorts and
  • data collection, processing and/or analysis of several core Danish cohorts and trials.

Methods

Epidemiological methods focus on the quantitative analysis of occurrence of health outcomes and their determinants at the level of populations. Epidemiological methods include study designs (sampling, data collection and processing, quality control), and statistical analytical approaches combined with subject matter knowledge.

The aim is to chart the distribution of health conditions and to determine causes of population health. Although different groups of researchers within the unit focus on different exposures and different health outcomes, the strength of the research unit lies in a shared focus on applying rigorous epidemiologic principles and methodological approaches and in the group’s ability to define, develop and apply the most appropriate scientific strategy to explore a given research question.

Recent publications

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Witte, D., Taskinen, M. R., Perttunen-Nio, H., Van Tol, A., Livingstone, S. & Colhoun, H. M. (2004). Study of agreement between LDL size as measured by nuclear magnetic resonance and gradient gel electrophoresis. Journal of Lipid Research, 45(6), 1069-76. https://doi.org/10.1194/jlr.M300395-JLR200
Witte, D., Tesfaye, S., Chaturvedi, N., Eaton, S. E. M., Kempler, P., Fuller, J. H. & EURODIAB Prospective Complications Study Group (2005). Risk factors for cardiac autonomic neuropathy in type 1 diabetes mellitus. Diabetologia, 48(1), 164-71. https://doi.org/10.1007/s00125-004-1617-y
Witte, D., Westerink, J., de Koning, E. J., van der Graaf, Y., Grobbee, D. E. & Bots, M. L. (2005). Is the association between flow-mediated dilation and cardiovascular risk limited to low-risk populations? Journal of the American College of Cardiology, 45(12), 1987-93. https://doi.org/10.1016/j.jacc.2005.02.073
Witte, D., Grobbee, D. E., Bots, M. L. & Hoes, A. W. (2005). A meta-analysis of excess cardiac mortality on Monday. European Journal of Epidemiology, 20(5), 401-6.
Witte, D., Grobbee, D. E., Bots, M. L. & Hoes, A. W. (2005). Excess cardiac mortality on Monday: the importance of gender, age and hospitalisation. European Journal of Epidemiology, 20(5), 395-9. https://doi.org/10.1007/s10654-004-6594-4
Witte, D., Shipley, M. J., Marmot, M. G. & Brunner, E. J. (2010). Performance of existing risk scores in screening for undiagnosed diabetes: an external validation study. Diabetic medicine : a journal of the British Diabetic Association, 27(1), 46-53. https://doi.org/10.1111/j.1464-5491.2009.02891.x

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